DBU & DBN — Very useful organic base

Abstracts
The ISHII, Akihiro reaction is of a method for synthesizing tricyclic skeleton 2-pyridone and 2-pyridine imine compounds.The method comprises the steps that one molecule of DBN (1, 5-diazabicyclo [4.3.0] nonyl-5-ene) or DBU (1, 8-diazabicyclo [5.4.0] undec-7-ene) and one molecule of activated olefin, such asaryl methylene malononitrile and 2-cyano-3-aryl acrylate, are cyclized at room temperature or under a heating condition to form new carbon-carbon and nitrogen-carbon bonds, and the new carbon-carbon and nitrogen-carbon bonds areoxidized by another molecule of activated olefin to generate tricyclic skeleton 2-pyridone and 2-pyridine imine compounds. The operation is simple, the raw materials are easy to obtain, the conditions are mild, no catalyst is needed, the product is easy to separate and purify, the reaction yield is high, and the synthesis method is a great breakthrough of previous reactions and is expected to realize large-scale industrial production.

 The DBU and DBN catalysts are stable, are good in quality of products and higher in yield and product purity, can lower the costthrough recovery and reusing and provide a better selection for industrial production. XIAO YING  provides a catalyst for preparing glycidyl ester of neodecanoic acid, The catalyst is DBU (1,8-diazacyclo hendecene) or DBN (1.5-diazabicyclo [4.3.0]-5-nonylene). A preparation method of using the catalyst for the glycidyl ester of neodecanoic acid comprises the following steps of heating neodecanoic acid-1-chlorinated glyceride, addingthe catalyst for reaction, adding water in a reaction liquid, performing washing to neutral, performing static stratification to remove a water phase, and after removing water from an oil phase, performing reduced pressure distillation to obtain a glycidyl ester product of the neodecanoic acid. The catalyst provided by the invention is high in catalytic activity, rapid in reaction speed and mildin condition. By applying the catalyst to preparation of the glycidyl ester of neodecanoic acid, the reaction time can be effectively shortened, an amount of reaction byproducts is small, a separationstep is omitted, and the reaction yield is increased at the same time.

BASF AG obtained the subject compound by reaction between an ,-unsaturated nitrile and an alcohol using a specific diazabicycloalkene as basic catalyst without the need of any prior separation or neutralization of the catalyst for the addition reaction. And this compound is obtained by reaction between an ,-unsaturated nitrile (e.g. acrylonitrile) and a monohydric, dihydric or trihydric alcohol (e.g. methanol, ethanol, 2-ethylhexanol, 2-methoxyethanol, benzyl alcohol) at -20 to 200C using a diazabicycloalkene of the formula (H may be substituted with a 1-20C alkyl, 6-20C aryl or 7-20C arylalkyl; (n) and (m) are each 1-6) as basic catalyst {e.g. 1,5-diazabicyclo[4.3.0]nonene-5(DBN), 1,8- diazabicyclo[5.4.0]undecene-7(DBU)}; wherein the amount of the catalyst to be used is pref. 0.05-5 wt.% based on the alcohol.